1　　

Yoshihiro Watanabe,Takako Ohbayashi, Ikuo Okafuji, Shigeki Kato, Satoko Tamai,Kiyoaki Ito, Natsuko Hosokawa, Mitsuhiro Kawano , Yusei OhshimaEpitope profiling of cow’s milk allergen-specific antibodies withdetermining IgE content in epitopes-ALL, a 14-epitopes mixture ，Journal of Immunological Metho.535(2024)113773.

2　　

Fujita H, Arai S, Arakawa H, Hamamoto K, Kato T, Arai T, Nitta N, Hotta K, Hosokawa N, Ohbayashi T, Takahashi C, Inokuma Y, Tamai I, Yano S, Kunishima M, Watanabe Y. Drug-drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers Bioorg Med Chem, 2024 Mar 15:102:117674. doi: 10.1016/j.bmc.2024.117674. Epub 2024 Mar 2.

3

Watanabe Y, Hosokawa N, Yoshida M, Miura T, Kawano M. Identification of closed linear epitopes in S1-RBD and S2-HR1/2 of SARS-CoV-2 Spike protein able to induce neutralizing Abs. Vaccines, 11: 287, 2023.

4

Tsuge S, Mizushima I, Horita M, Kawahara H, Sanada H, Yoshida M, Takahashi Y, Zoshima T, Nishioka R, Hara S, Suzuki Y, Ito K, Kawano M. High serum IgA levels in patients with IgG4-related disease (IgG4-RD) are associated with mild inflammation, sufficient disease- specific features, and favorable responses to treatments. Mod Rheumatol. Road056 2023.

5

Sugimoto H, Toya T, Watanabe Y, Takei W, Nagai R, Donjo Y, Motoo R, Inaba M, Yoshizaki T, Murakoshi M.　Wideband frequency impedance for diagnosis of ossicular chain abnormality.　Acta Otolaryngol. 143(11-12):958-964, 2023.

6

Hamaoka S, Takahira M, Kawano M, Yamada K, Ito K, Okuda T, Hatake S, Malissen M,Malissen B, Sugiyama K. Lacrimal Gland and Orbital Lesions in LatY136F Knock-in Mice, a Model for Human IgG4-Related Ophthalmic Disease. Curr Eye Res. 47:1405-1412, 2022.

7

Waseda Y, Yamada K, Mizuguchi K, Ito K, Watanabe S, Zuka M, Ishizuka T, Malissen M, Malissen B, Kawano M, Matsui S. The pronounced lung lesions developing in LATY136F knock-in mice mimic human IgG4-related lung disease. PLoS One. 16(3): e0247173, 2021.

8

Honda F, Tsuboi H, Ono Y, Abe S, Takahashi H, Ito K, Yamada K, Kawano M, Kondo Y, Asano K, Tanaka M, Malissen M, Malissen B, Matsumoto I, Sumida T. Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis. Arthritis Res Ther. 23:214, 2021.

9

Linn P, Kohno S, Sheng J, Kulathunga N, Yu H, Zhang Z, Voon D, Watanabe Y, Takahashi T. Targeting RB1 Loss in Cancers. Cancers (Basel), 13:3737, 2021.

10

Sakamoto S, Kirinashizawa M, Mohara Y, Watanabe Y. Generation and characterization of monoclonal antibodies against mature hepcidin and its application to neutralization and quantitative alteration assay. Bioscience, Biotechnology, and Biochemistry, 85:340-350, 2021.

11

Mizushima I, Yamano T, Kawahara H, Hibino S, Nishioka R, Zoshima T, Hara S, Ito K, Fujii H, Nomura H, Kawano M. Positive disease-specific autoantibodies have limited clinical significance in diagnosing IgG4-related disease in daily clinical practice. Rheumatology (Oxford). 60:3317-3325, 2021.

12

Mizushima I, Konishi M, Sanada H, Suzuki K, Takeji A, Zoshima T, Hara S, Ito K, Fujii H, Yamada K, Kawano M. Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease. Sci Rep. 11:13341, 2021.

13

Nakashima A, Horita S, Matsunaga T, Inoue R, Zoshima T, Mizushima I, Hara S, Ito K, Fujii H, Nomura H, Kawano M. Factors contributing to discrepant estimated glomerular filtration values measured by creatinine and cystatin C in patients with rheumatoid arthritis. Sci Rep. 11:9884, 2021.

14

Kohno , Linn O, Nagatani N, Watanabe Y, Kumar S, Soga,T, Takahashi C. Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. Oncogene, 34:5690-5707, 2020.

15

Futami M, Suzuki K, Kato S, Ohmae S, Tahara Y, Nojima M, Imai Y, Mimura T, Watanabe Y, Tojo A. The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells. PlosOne, 15:e0231896, 2020.

16

Futami M, Suzuki K, Kato S, Ohmae S, Tahara Y, Nojima M, Imai Y, Mimura T, Watanabe Y, Tojo A. Therapeutic Targeting of Monokine Production Is a Promising Strategy to Attenuate Cytokine-Release Syndrome in CAR-T Cell Therapy. Blood, 134 (Supplement_1): 206, 2019.

17

Ito K, Hara S, Yamada K, Zoshima T, Mizushima I, Fujii H, Miyazaki R, Kawai Y, Yachie A, Nagata M, Izui S, Yamagishi M, Kawano M. A case report of crystalline light chain inclusion-associated kidney disease affecting podocytes but without Fanconi syndrome: A clonal analysis of pathological monoclonal light chain. Medicine (Baltimore). 98:e13915, 2019.

（過去５年間）

２）国際会議・国際学会

1

Yoshihiro Watanabe.
Identification of neutralizing Ab-epitopes in RBD and HR2 of SARS CoV-2 Spike antigen, and their utilization.
International Vaccine Research & Development, 2023, Nov.3-5, Baltimore, MD, USA.

2

Yoshihiro Watanabe.
Discovery of JTP-74057/GSK1120212/Trametinib as a MEK-Inhibitor able to alter Phosphorylation State of MEK.
Keystone Symposia. Phenotype Drug Discovery: Recent advances and insights from chemical and systems biology. 2019, March 3-7, Breckenridge, CO, USA.